Okky Dwichandra Putra

Nov 4, 2024 | pubs.rsc.org | David Whalley |Luca Carlino |Okky Dwichandra Putra |Niall Anderson

Merging Nucleophilic Phosphine Catalysis and Photocatalysis for the Rapid Assembly of 2-Oxabicyclo-[2.1.1]hexane Scaffolds from Feedstock Allyl Alcohols The previously unreported combination of nucleophilic phosphine catalysis and energy transfer catalysis allows for the rapid construction of structurally distinct 2-oxabicyclo[2.1.1]hexanes (2-oxa-BCH) from readily available building blocks with high atom economy.

Dec 12, 2023 | nature.com | Daniele Antermite |Stig D. Friis |Johan Johansson |Okky Dwichandra Putra |Lutz Ackermann

AbstractPROteolysis TArgeting Chimeras (PROTACs) are heterobifunctional molecules emerging as a powerful modality in drug discovery, with the potential to address outstanding medical challenges. However, the synthetic feasibility of PROTACs, and the empiric and complex nature of their structure-activity relationships continue to present formidable limitations. As such, modular and reliable approaches to streamline the synthesis of these derivatives are highly desirable.