Dasa Bohaciakova

Feb 14, 2024 | nature.com | Marian Hruska-Plochan |Vera I. Wiersma |Katharina M. Betz |Elena Tantardini |Florent Laferrière |Igor Delvendahl | +11 more

AbstractHuman cellular models of neurodegeneration require reproducibility and longevity, which is necessary for simulating age-dependent diseases. Such systems are particularly needed for TDP-43 proteinopathies1, which involve human-specific mechanisms2,3,4,5 that cannot be directly studied in animal models.

Sep 1, 2023 | biorxiv.org | Durga Jha |Tereza Vanova |Dasa Bohaciakova |Zdenek Spacil

AbstractBeta and gamma-secretase inhibitors have been of pharmacological interest to reduce abeta (Aβ) formation and aggregation, a defining characteristic of Alzheimer's disease (AD). Recent research indicates that Apolipoprotein E (ApoE), another genetic risk factor for AD, can regulate secretase activity. Secretase inhibitor-induced elevation of neuronal membrane lipids has been documented in 2D models.