David Enard

Nov 27, 2024 | nature.com | Irepan Salvador-Martínez |Jesus Murga-Moreno |Juan Nieto |Clara Alsinet |David Enard

AbstractHuman immune cells are under constant evolutionary pressure, primarily through their role as first line of defence against pathogens. Most studies on immune adaptation are, however, based on protein-coding genes without considering their cellular context. Here, using data from the Human Cell Atlas, we infer the gene adaptation rate of the human immune landscape at cellular resolution.