Irepan Salvador-Martínez

Nov 27, 2024 | nature.com | Irepan Salvador-Martínez |Jesus Murga-Moreno |Juan Nieto |Clara Alsinet |David Enard

AbstractHuman immune cells are under constant evolutionary pressure, primarily through their role as first line of defence against pathogens. Most studies on immune adaptation are, however, based on protein-coding genes without considering their cellular context. Here, using data from the Human Cell Atlas, we infer the gene adaptation rate of the human immune landscape at cellular resolution.

Oct 6, 2023 | biorxiv.org | Irepan Salvador-Martínez |Jesus Murga-Moreno |Juan Nieto |Clara Alsinet

AbstractThe human immune system is under constant evolutionary pressure, primarily through its role as first line of defence against pathogens. Accordingly, population genomics studies have shown that immune-related genes have a high rate of adaptive evolution. These studies, however, are mainly based on protein-coding genes without cellular context, leaving the adaptive role of cell types and states uncharted.