David Jiang

Jan 21, 2025 | biorxiv.org | Andrew Robinson |David Jiang |Abbey Nkansah |Jonathan Leung

AbstractSmall diameter vascular grafts require a complex balance of biomechanical properties to achieve target burst pressure, arterial compliance-matching, and kink resistance to prevent failure. Iterative design of our multilayer vascular was previously used to achieve high compliance while retaining the requisite burst pressure and suture retention strength for clinical use.

Sep 7, 2024 | biorxiv.org | David Jiang |Andrew Robinson |Abbey Nkansah |Jonathan Leung

AbstractThe failure of synthetic small-diameter vascular grafts has been attributed to a mismatch in the compliance between the graft and native artery, driving mechanisms that promote thrombosis and neointimal hyperplasia. Additionally, the buckling of grafts results in large deformations that can lead to device failure. Although design features can be added to lessen the buckling potential, the addition is detrimental to decreasing compliance (e.g., reinforcing coil).