David L. Steer

Oct 7, 2024 | nature.com | Brooke K Hayes |Marina Harper |Jessica Lewis |Joel Steele |David L. Steer |Ralf B. Schittenhelm | +1 more

AbstractThe type VI secretion system (T6SS) is a molecular machine utilised by many Gram-negative bacteria to deliver antibacterial toxins into adjacent cells. Here we present the structure of Tse15, a T6SS Rhs effector from the nosocomial pathogen Acinetobacter baumannii. Tse15 forms a triple layered β-cocoon Rhs domain with an N-terminal α-helical clade domain and an unfolded C-terminal toxin domain inside the Rhs cage.