David Suster

Apr 19, 2023 | jcp.bmj.com | Aswathy Ashok Menon |Vikram Deshpande |David Suster

Aswathy Ashok Menon1, http://orcid.org/0000-0003-4230-9308Vikram Deshpande2, David Suster3 1 Department of Pathology, Neuberg Anand Reference Laboratory, Bengaluru, Karnataka, India 2 Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Department of Pathology, Rutgers University New Jersey Medical School, Newark, New Jersey, USA Correspondence to Dr David Suster; dssusterdi{at}gmail.com Abstract The mouse double minute 2 (MDM2) gene is located on the long arm...

Apr 19, 2023 | jcp.bmj.com | Aswathy Ashok Menon |Vikram Deshpande |David Suster

IntroductionThe mouse double minute 2 (MDM2) gene is one of the most critical negative regulators of p53, a protein colloquially referred to as the guardian of the genome. MDM2 overexpression is known to have a tumorigenic effect through the inactivation of normal p53 tumour suppressor function. Alterations of the MDM2 gene have been reported in sarcomas, carcinomas, glioblastoma and some haematological malignancies.