David Suster

Apr 19, 2023 | jcp.bmj.com | Aswathy Ashok Menon |Vikram Deshpande |David Suster

Aswathy Ashok Menon1, http://orcid.org/0000-0003-4230-9308Vikram Deshpande2, David Suster3 1 Department of Pathology, Neuberg Anand Reference Laboratory, Bengaluru, Karnataka, India 2 Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Department of Pathology, Rutgers University New Jersey Medical School, Newark, New Jersey, USA Correspondence to Dr David Suster; dssusterdi{at}gmail.com Abstract The mouse double minute 2 (MDM2) gene is located on the long arm...

Apr 19, 2023 | jcp.bmj.com | Aswathy Ashok Menon |Vikram Deshpande |David Suster

IntroductionThe mouse double minute 2 (MDM2) gene is one of the most critical negative regulators of p53, a protein colloquially referred to as the guardian of the genome. MDM2 overexpression is known to have a tumorigenic effect through the inactivation of normal p53 tumour suppressor function. Alterations of the MDM2 gene have been reported in sarcomas, carcinomas, glioblastoma and some haematological malignancies.

Mar 10, 2023 | jcp.bmj.com | Vikram Deshpande |David Suster |Aswathy Ashok Menon

Aswathy Ashok Menon1, http://orcid.org/0000-0003-4230-9308Vikram Deshpande2, David Suster3 1Department of Pathology, Neuberg Anand Reference Laboratory, Bengaluru, Karnataka, India 2Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA 3Department of Pathology, Rutgers University New Jersey Medical School, Newark, New Jersey, USA Correspondence to Dr David Suster; dssusterdi{at}gmail.com Abstract The mouse double minute 2 (MDM2) gene is located on the long arm of...