David Talavera

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Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets - Nature Communications

Mar 18, 2024 | nature.com | Xiaoguang Xu |Chachrit Khunsriraksakul |James M. Eales |David Talavera |Lida Wang |Abigail C. Lay | +8 more

AbstractGenetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-specific epigenomic annotations and 3D genome information we generated and validated gene expression prediction models for the purpose of transcriptome-wide association studies in 700 human kidneys. We identified 889 kidney genes associated with BP of which 399 were prioritised as contributors to BP regulation.

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