Abigail C. Lay

Nov 18, 2024 | nature.com | Abigail C. Lay |Frédéric Burdet |Florence Mehl |Dmytro Kryvokhyzha |Abrar Ahmad |Matthew Sinton | +9 more

AbstractDiabetic kidney disease (DKD) is the leading cause of end stage kidney failure worldwide, of which cellular insulin resistance is a major driver. Here, we study key human kidney cell types implicated in DKD (podocytes, glomerular endothelial, mesangial and proximal tubular cells) in insulin sensitive and resistant conditions, and perform simultaneous transcriptomics and proteomics for integrated analysis.

Mar 18, 2024 | nature.com | Xiaoguang Xu |Chachrit Khunsriraksakul |James M. Eales |David Talavera |Lida Wang |Abigail C. Lay | +8 more

AbstractGenetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-specific epigenomic annotations and 3D genome information we generated and validated gene expression prediction models for the purpose of transcriptome-wide association studies in 700 human kidneys. We identified 889 kidney genes associated with BP of which 399 were prioritised as contributors to BP regulation.