Davide Corti

Jan 7, 2025 | nature.com | Davide Corti

Correction to: Communications Medicine (2024) 4:244; https://doi.org/10.1038/s43856-024-00633-5; Article published online 22 November 2024The published document was missing the information that the authors obtained permission to use the WWSCAN wastewater data, as described in data.wastewaterscan.org.

Nov 22, 2024 | nature.com | Davide Corti

AbstractThere are three possible SARS-CoV-2 post-pandemic scenarios: (i) ongoing severity, (ii) influenza-like severity, and (iii) a transition to an endemic disease with lesser morbidity similar to that of other human coronaviruses. To assess a possible evolution of the pandemic under the three scenarios, we use data from the US National Covid Cohort Collaborative, CDC COVID-NET, and CDC Fluview and from the WastewaterSCAN Dashboard.

Oct 30, 2024 | nature.com | Matthew McCallum |Qing Xiong |Davide Corti |David Veesler |Zheng-Li Shi

AbstractAlthough coronaviruses use diverse receptors, the characterization of coronaviruses with unknown receptors has been impeded by a lack of infection models1,2. Here we introduce a strategy to engineer functional customized viral receptors (CVRs). The modular design relies on building artificial receptor scaffolds comprising various modules and generating specific virus-binding domains.

Jun 27, 2024 | nature.com | Cameron Stewart |Alexandra Schafer |Young-Jun Park |John Powers |Davide Corti |Ralph S Baric | +1 more

AbstractEvolution of SARS-CoV-2 alters the antigenicity of the immunodominant spike (S) receptor-binding domain and N-terminal domain, undermining the efficacy of vaccines and antibody therapies. To overcome this challenge, we set out to develop a vaccine focusing antibody responses on the highly conserved but metastable S2 subunit, which folds as a spring-loaded fusion machinery.

Aug 30, 2023 | nature.com | Luca Piccoli |James Case |Young-Jun Park |Kaitlin R Sprouse |Jessica Bassi |Christian Saliba | +25 more

AbstractCurrently circulating SARS-CoV-2 variants have acquired convergent mutations at hot spots in the receptor-binding domain1 (RBD) of the spike protein. The effects of these mutations on viral infection and transmission and the efficacy of vaccines and therapies remains poorly understood. Here we demonstrate that recently emerged BQ.1.1 and XBB.1.5 variants bind host ACE2 with high affinity and promote membrane fusion more efficiently than earlier Omicron variants.