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1 month ago | 
nature.com | Sofie Jacobs |Jordi Doijen |Rana Abdelnabi |Michiel Van Gool |Alexandra Schafer |Dirk Jochmans | +12 more
AbstractThe membrane (M) protein of betacoronaviruses is well conserved and has a key role in viral assembly1,2. Here we describe the identification of JNJ-9676, a small-molecule inhibitor targeting the coronavirus M protein. JNJ-9676 demonstrates in vitro nanomolar antiviral activity against SARS-CoV-2, SARS-CoV and sarbecovirus strains from bat and pangolin zoonotic origin.
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Dec 6, 2024 | 01387-1&sz=64)
cell.com | Kaitlin R Sprouse |Marcos Miranda |Nicholas J. Catanzaro |Amin Addetia |Cameron Stewart |Jack Brown | +19 more
KeywordsMERS-CoVEMPEMnanoparticlevaccineRBDNTDspikeResearch topic(s)CP: ImmunologyIntroductionThe recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has demonstrated the human and economic toll that can accompany the spillover and spread of a zoonotic disease in humans. Although the success of vaccine development efforts in response to the pandemic were a triumph of modern vaccinology, SARS-CoV-2 remains the only coronavirus for which licensed vaccines are available.
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Nov 13, 2024 | 
science.org | Sharon Saydah |Michael J Peluso |Julio César Silva |Júlio Silva |Alexandra Schafer
AbstractThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) pandemic has caused more than 7 million deaths globally. Despite the presence of infection- and vaccine-induced immunity, SARS-CoV-2 infections remain a major global health concern because of the emergence of SARS-CoV-2 variants that can cause severe acute coronavirus disease 2019 (COVID-19) or enhance Long Covid disease phenotypes.
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Jun 27, 2024 | 
nature.com | Cameron Stewart |Alexandra Schafer |Young-Jun Park |John Powers |Davide Corti |Ralph S Baric | +1 more
AbstractEvolution of SARS-CoV-2 alters the antigenicity of the immunodominant spike (S) receptor-binding domain and N-terminal domain, undermining the efficacy of vaccines and antibody therapies. To overcome this challenge, we set out to develop a vaccine focusing antibody responses on the highly conserved but metastable S2 subunit, which folds as a spring-loaded fusion machinery.
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May 3, 2024 | 
nature.com | Elizabeth Anderson |Jennifer Diaz |Sarah R. Leist |Alexandra Schafer |John Powers |Ralph S Baric | +2 more
AbstractWhole virus-based inactivated SARS-CoV-2 vaccines adjuvanted with aluminum hydroxide have been critical to the COVID-19 pandemic response.
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Apr 21, 2024 | 00455-8&sz=64)
cell.com | Alexandra Schafer |Andrea Marzi |Wakako Furuyama |Nicholas J. Catanzaro
Highlights•CC genetic reference population identifies genetic loci regulating EBOV pathogenesis in mice•An F2 population from two CC lines is either highly resistant or vulnerable to EBOV infection•A major locus on chromosome 7, encoding Trim5, drives severe EVD-like disease in mice•Gene expression signatures of liver damage mirror severe EVD in humansSummaryEbola virus (EBOV), a major global health concern, causes severe, often fatal EBOV disease (EVD) in humans.
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Nov 6, 2023 | 
science.org | John G. McKendrick |P. Kent Langston |Rosanne Spolski |Alexandra Schafer
AbstractNon-antigen vaccines that broadly activate innate immune responses reduce mortality against hospital-acquired bacterial and fungal pathogens. SIGN UP FOR THE SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily Nosocomial or health care–associated infections (HAI) affect ~10% of all in-care patients, causing severe complications, often delaying discharge, and imposing a tremendous financial burden on the health care systems.
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Nov 3, 2023 | 
sciencemag.org | John G. McKendrick |P. Kent Langston |Rosanne Spolski |Alexandra Schafer
Editors' ChoiceFOCIS HIGHLIGHTSNosocomial or health care–associated infections (HAI) affect ~10% of all in-care patients, causing severe complications, often delaying discharge, and imposing a tremendous financial burden on the health care systems. A wide range of often unrelated pathogens, including Gram-negative and Gram-positive bacteria and fungal pathogens, cause HAI. Yet they share one thing in common: They are antimicrobial resistant (AMR).
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Oct 18, 2023 | 01260-3&sz=64)
cell.com | David Martinez |David Martínez |Alexandra Schafer |Tyler D. Gavitt |Michael Mallory
Highlights • A trivalent RBD nanoparticle vaccine elicits broadly cross-reactive antibodies • Trivalent RBD nanoparticle vaccine elicits BA.1 and XBB.1.5 neutralizing antibodies • Vaccine-mediated protection against lethal SARS-CoV and pathogenic MERS-CoV • A single vaccine protects against group 2b/2c betacoronavirus challenge in mice Summary The emergence of three highly pathogenic human coronaviruses—severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003, Middle Eastern...
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Oct 18, 2023 | cell.com | David Martinez |David Martínez |Alexandra Schafer |Tyler D. Gavitt |Michael Mallory
Highlights • A trivalent RBD nanoparticle vaccine elicits broadly cross-reactive antibodies • Trivalent RBD nanoparticle vaccine elicits BA.1 and XBB.1.5 neutralizing antibodies • Vaccine-mediated protection against lethal SARS-CoV and pathogenic MERS-CoV • A single vaccine protects against group 2b/2c betacoronavirus challenge in mice Summary The emergence of three highly pathogenic human coronaviruses—severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003, Middle Eastern...
