Dawson B Ling

Aug 18, 2023 | nature.com | Emma Pietsch |Dawson B Ling |Paul McMillan |Paul Gilson |Leann Tilley

AbstractThe malaria parasite uses actin-based mechanisms throughout its lifecycle to control a range of biological processes including intracellular trafficking, gene regulation, parasite motility and invasion. In this work we assign functions to the Plasmodium falciparum formins 1 and 2 (FRM1 and FRM2) proteins in asexual and sexual blood stage development. We show that FRM1 is essential for merozoite invasion and FRM2 is required for efficient cell division.