Paul McMillan

New York

Managing Editor at With Intelligence

Heading up the global editorial teams at With Intelligence, providing actional intel to sales and IR pros across asset management.

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Articles

Plasmodium falciparum formins are essential for invasion and sexual stage development - Communications Biology

Aug 18, 2023 | nature.com | Emma Pietsch |Dawson B Ling |Paul McMillan |Paul Gilson |Leann Tilley

AbstractThe malaria parasite uses actin-based mechanisms throughout its lifecycle to control a range of biological processes including intracellular trafficking, gene regulation, parasite motility and invasion. In this work we assign functions to the Plasmodium falciparum formins 1 and 2 (FRM1 and FRM2) proteins in asexual and sexual blood stage development. We show that FRM1 is essential for merozoite invasion and FRM2 is required for efficient cell division.

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