Debora S. Marks

Jul 2, 2023 | genomebiology.biomedcentral.com | Douglas Fowler |David Adams |Anna L Gloyn |William Hahn |Debora S. Marks |James Neal | +5 more

Compiling a complete Atlas of Variant Effects for all 20,000 human genes, not to mention potentially hundreds of thousands of noncoding regulatory elements, will require an international collaborative effort involving thousands of researchers, clinicians and technologists. Comparing this initiative to some of the landmark genomic collaborative achievements of the past 30 years highlights some of the key challenges to be addressed.

May 8, 2023 | nature.com | Davide Placido |Chunlei Zheng |Amalie D. Haue |Piotr Chmura |Renato Umeton |Debora S. Marks | +5 more

AbstractPancreatic cancer is an aggressive disease that typically presents late with poor outcomes, indicating a pronounced need for early detection. In this study, we applied artificial intelligence methods to clinical data from 6 million patients (24,000 pancreatic cancer cases) in Denmark (Danish National Patient Registry (DNPR)) and from 3 million patients (3,900 cases) in the United States (US Veterans Affairs (US-VA)).