-
Jan 7, 2025 | 00365-6?rss=yes&sz=64)
cell.com | Jessica D. Ewald |Yao Lu |Cara E. Ellis |Jessica Worton |Jelena Kolic |Shugo Sasaki | +25 more
ForumVolume 37, Issue 1p7-11 1Institute of Parasitology, McGill University, Montreal, QC, Canada 2Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA 3Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada 4Department of Pharmacology, University of Alberta, Edmonton, AB, Canada 5Department of Surgery, University of Alberta, Edmonton, AB, Canada 6Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia,...
-
Jan 7, 2025 | cell.com | Jessica D. Ewald |Yao Lu |Cara E. Ellis |Jessica Worton |Jelena Kolic |Shugo Sasaki | +25 more
ForumVolume 37, Issue 1p7-11 1Institute of Parasitology, McGill University, Montreal, QC, Canada 2Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA 3Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada 4Department of Pharmacology, University of Alberta, Edmonton, AB, Canada 5Department of Surgery, University of Alberta, Edmonton, AB, Canada 6Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia,...
-
Oct 22, 2024 | 
nature.com | Silvia Bonas-Guarch |Fanny Mollandin |Joanne Cole |Josephine H. Li |Jose C. Florez |Anna L Gloyn | +4 more
Correction to: Nature Genetics https://doi.org/10.1038/s41588-024-01947-9, published online 8 October 2024. In the version of the article initially published, Alicia Huerta-Chagoya, Philip Schroeder, Ravi Mandla and Jiang Li were not listed as equal contributors and Uyenlinh L. Mirshahi, Alisa K. Manning, Aaron Leong, Miriam Udler and Josep M. Mercader were not listed as having jointly supervised the work. These corrections have been made to the HTML and PDF versions of the article.
-
Oct 8, 2024 | 
nature.com | Silvia Bonas-Guarch |Joanne Cole |Josephine H. Li |Jose C. Florez |Anna L Gloyn |Inês Cebola | +4 more
AbstractType 2 diabetes (T2D) genome-wide association studies (GWASs) often overlook rare variants as a result of previous imputation panels’ limitations and scarce whole-genome sequencing (WGS) data. We used TOPMed imputation and WGS to conduct the largest T2D GWAS meta-analysis involving 51,256 cases of T2D and 370,487 controls, targeting variants with a minor allele frequency as low as 5 × 10−5.
-
Jul 25, 2024 | 00703-7&sz=64)
cell.com | Byrne C.D |E. Dale Abel |Anna L Gloyn |Joshua Joseph
SummaryDiabetes, a complex multisystem metabolic disorder characterized by hyperglycemia, leads to complications that reduce quality of life and increase mortality. Diabetes pathophysiology includes dysfunction of beta cells, adipose tissue, skeletal muscle, and liver. Type 1 diabetes (T1D) results from immune-mediated beta cell destruction.
-
Jul 2, 2024 | 00226-2?rss=yes&sz=64)
cell.com | Jelena Kolic |Wenqing Sun |Haoning Cen |Jessica D. Ewald |Jason C. Rogalski |Shugo Sasaki | +14 more
Keywordshuman isletstype 2 diabetesstem cell-derived isletsinsulin secretionproteomicsmacronutrientsRNA-seqIntroductionInsulin is released by pancreatic islet beta cells in response to nutrient stimuli to maintain energy homeostasis. The major driver of insulin secretion is glucose. However, proteins and fats may also modulate insulin release, and the effects of non-carbohydrate nutrients on insulin secretion remain underexplored.
-
Jul 1, 2024 | 
nature.com | Anna L Gloyn |Mark Ibberson |Alvin C. Powers |Patrik Rorsman
Correction to: Nature Metabolism https://doi.org/10.1038/s42255-022-00607-8, published online 11 August 2022In the version of this article initially published, the name of the Human Pancreas Analysis Program was written incorrectly and has now been amended in the HTML and PDF versions of the article. About this articleGloyn, A.L., Ibberson, M., Marchetti, P. et al. Author Correction: Every islet matters: improving the impact of human islet research. Nat Metab (2024).
-
Sep 30, 2023 | 
nature.com | Yunkyeong Lee |Han Sun |Daphne Su-Lyn Gardner |E. Shyong Tai |Anna L Gloyn |Hwee Hui Lau | +1 more
AbstractThe coding variant (p.Arg192His) in the transcription factor PAX4 is associated with an altered risk for type 2 diabetes (T2D) in East Asian populations. In mice, Pax4 is essential for beta cell formation but its role on human beta cell development and/or function is unknown.
-
Sep 28, 2023 | 
biomedcommunity.springernature.com | Katharine R Owen |Pål Rasmus Njølstad |Anna L Gloyn |Rinki Murphy
Diagnostic genetic testing for monogenic diabetes has been available since the late 1990’s; however, implementation into clinical practice has been patchy, led by enthusiasts and researchers. Access to testing is variable between and within countries and remains a missed opportunity to implement precision medicine for diabetes.
-
Sep 28, 2023 | biomedcommunity.springernature.com | Katharine R Owen |Pål Rasmus Njølstad |Anna L Gloyn |Rinki Murphy
Diagnostic genetic testing for monogenic diabetes has been available since the late 1990’s; however, implementation into clinical practice has been patchy, led by enthusiasts and researchers. Access to testing is variable between and within countries and remains a missed opportunity to implement precision medicine for diabetes.
