Deepthi P. Mallela

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Gut microbe-generated phenylacetylglutamine is an endogenous allosteric modulator of β2-adrenergic receptors - Nature Communications

Aug 5, 2024 | nature.com | James Anderson |Deepthi P. Mallela |Niladri S. Kar |Terri J. Harford |Michael Fischbach |J. Brown | +3 more

AbstractAllosteric modulation is a central mechanism for metabolic regulation but has yet to be described for a gut microbiota-host interaction. Phenylacetylglutamine (PAGln), a gut microbiota-derived metabolite, has previously been clinically associated with and mechanistically linked to cardiovascular disease (CVD) and heart failure (HF).

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