Michael Fischbach

Dec 11, 2024 | nature.com | Inta Gribonika |Verena M. Link |Eduard Ansaldo |Cihan Oguz |Djenet Bousbaine |Michael Fischbach

AbstractThe microbiota colonizes each barrier site and broadly controls host physiology1. However, when uncontrolled, microbial colonists can also promote inflammation and induce systemic infection2. The unique strategies employed at each barrier tissue to control the coexistence of the host with its microbiota remain largely elusive. Here we uncover that, within the skin, host-microbiota symbiosis depends on the remarkable ability of the skin to act as an autonomous lymphoid organ.

Aug 5, 2024 | nature.com | James Anderson |Deepthi P. Mallela |Niladri S. Kar |Terri J. Harford |Michael Fischbach |J. Brown | +3 more

AbstractAllosteric modulation is a central mechanism for metabolic regulation but has yet to be described for a gut microbiota-host interaction. Phenylacetylglutamine (PAGln), a gut microbiota-derived metabolite, has previously been clinically associated with and mechanistically linked to cardiovascular disease (CVD) and heart failure (HF).

Apr 11, 2024 | cell.com | Michael Fischbach |Chan Zuckerberg Biohub

Scientists and engineers often spend days choosing a problem and years solving it. This imbalance limits impact. Here, we offer a framework for problem choice: prompts for ideation, guidelines for evaluating impact and likelihood of success, the importance of fixing one parameter at a time, and opportunities afforded by failure. Main textThere are a finite number of weeks in one’s career.

Jan 24, 2024 | sciencedirect.com | A. Agarwal |Michael Fischbach |J. Rehm |Y. B. Chen |Y. S. Al Chen

Infertility occurs in approximately 8–12% of couples at reproductive age, and males account for 50% of infertile individuals (Agarwal et al., 2021). Notably, the sperm count has decreased by over 50% and has been of poor quality in most countries during recent decades (Sengupta et al., 2017).

Feb 13, 2023 | nature.com | Victòria Pascal Andreu |Hannah E. Augustijn |Lianmin Chen |Alexandra Zhernakova |Jingyuan Fu |Michael Fischbach | +1 more

AbstractThe gut microbiota produce hundreds of small molecules, many of which modulate host physiology. Although efforts have been made to identify biosynthetic genes for secondary metabolites, the chemical output of the gut microbiome consists predominantly of primary metabolites.