Diana Jurk

Jun 2, 2024 | nature.com | Vidyani Suryadevara |Adam D. Hudgins |Alberto Pappalardo |Alla Karpova |Amit K. Dey |Birgit Schilling | +23 more

AbstractOnce considered a tissue culture-specific phenomenon, cellular senescence has now been linked to various biological processes with both beneficial and detrimental roles in humans, rodents and other species. Much of our understanding of senescent cell biology still originates from tissue culture studies, where each cell in the culture is driven to an irreversible cell cycle arrest.

Jan 2, 2024 | nature.com | Stella G. Victorelli |James Chapman |Joel Riley |Diana Jurk |Lilian Sales Gomez |Joshua N Farr | +11 more

Correction to: Nature https://doi.org/10.1038/s41586-023-06621-4 Published online 11 October 2023In the version of this article initially published, US NIH grants R33AG61456-4 and R01AG064165 were missing from the Acknowledgements section and have now been inserted in the HTML and PDF versions of the article.

Oct 11, 2023 | nature.com | Stella G. Victorelli |James Chapman |Joel Riley |Diana Jurk |Lilian Sales Gomez |Joshua N Farr | +11 more

AbstractSenescent cells drive age-related tissue dysfunction partially through the induction of a chronic senescence-associated secretory phenotype (SASP)1. Mitochondria are major regulators of the SASP; however, the underlying mechanisms have not been elucidated2. Mitochondria are often essential for apoptosis, a cell fate distinct from cellular senescence. During apoptosis, widespread mitochondrial outer membrane permeabilization (MOMP) commits a cell to die3.