dianna perez

Jul 6, 2024 | biorxiv.org | Holly Conway |dianna perez |Mugtaba Swar-Eldahab |Jon Pignanelli

AbstractType 1 diabetes (T1D) results in immune-mediated destruction of insulin-producing beta cells I the pancreas. B cells have been identified as critical antigen presenting cells and their specificity drives disease progression. More recently, they have also been shown to have the capacity to develop into suppressive, regulatory B cells that ameliorate autoimmune disease in animal models of rheumatoid arthritis and multiple sclerosis.

Apr 6, 2024 | nature.com | Jamie Felton |S. Alice Long |Suna Onengut-Gumuscu |Stephen S. Rich |dianna perez |Linda A. DiMeglio | +2 more

AbstractIslet autoantibodies form the foundation for type 1 diabetes (T1D) diagnosis and staging, but heterogeneity exists in T1D development and presentation. We hypothesized that autoantibodies can identify heterogeneity before, at, and after T1D diagnosis, and in response to disease-modifying therapies.