Dibyendu Kumar Das

Oct 30, 2024 | elifesciences.org | Susmita Sarkar |Saurabh Gupta |Chiranjit Mahato |Dibyendu Kumar Das

A crucial question rises: Is ATP special in its role as an aggregate solubilizer? Toward this end, to investigate ATP’s relative efficiency in inducing the solubility of hydrophobic entities (biological macromolecules) within cells, we compared it to a conventional chemical hydrotrope sodium xylene sulfonate (NaXS), routinely used in various industrial applications to solubilize sparingly soluble compounds in water.

Oct 3, 2024 | cell.com | Molecular Biotechnology |Dibyendu Kumar Das

KeywordsSARS-CoV-2coronavirusviral entrymembrane fusionsingle molecule imagingconformational dynamicssmFRETGet full text accessLog in, subscribe or purchase for full access. References1. Harrison, S.C.Viral membrane fusionVirology. 2015; 479–480:498-5072. Kielian, M. Mechanisms of virus membrane fusion proteinsAnnu. Rev. Virol. 2014; 1:171-1893. Meng, B. ∙ Abdullahi, A. ∙ Ferreira, I.A.T.M. ... Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicityNature. 2022; 603:706-7144.

Aug 5, 2024 | biorxiv.org | Susmita Sarkar |Saurabh Gupta |Chiranjit Mahato |Dibyendu Kumar Das

AbstractProteins occurring in significantly high concentrations in cellular environments (over 100 mg/mL) and functioning in crowded cytoplasm, often face the prodigious challenges of aggregation which are the pathological hallmark of aging and are critically responsible for a wide spectrum of rising human diseases.

May 10, 2024 | biorxiv.org | Susmita Sarkar |Saurabh Gupta |Chiranjit Mahato |Dibyendu Kumar Das

AbstractProteins occurring in significantly high concentrations in cellular environments (over 100 mg/mL) and functioning in crowded cytoplasm, often face the prodigious challenges of aggregation which are the pathological hallmark of aging and are critically responsible for a wide spectrum of rising human diseases.

Jan 16, 2024 | biorxiv.org | Susmita Sarkar |Saurabh Gupta |Chiranjit Mahato |Dibyendu Kumar Das

AbstractProteins occurring in significantly high concentrations in cellular environments (over 100 mg/mL) and functioning in crowded cytoplasm, often face the prodigious challenges of aggregation which are the pathological hallmark of aging and are critically responsible for a wide spectrum of rising human diseases.