Didier Trono

Jan 25, 2024 | nature.com | Halit Ongen |Didier Trono

AbstractTransposable elements (TEs) are prevalent repeats in the human genome, play a significant role in the regulome, and their disruption can contribute to tumorigenesis. However, TE influence on gene expression in cancer remains unclear.

Nov 10, 2023 | genomebiology.biomedcentral.com | Cyril Pulver |Julien Duc |Evarist Planet | |Julien Pontis |Didier Trono | +1 more

H1 male and WIBR3 female human embryonic stem cells were provided by the Krause and Jaenisch lab, respectively, and both tested negative in the Mycoplasmacheck from eurofins Genomics upon receipt and throughout the study. Primed H1 were transduced with GFP or KLF4-containing lentiviral vectors and split after 48 h then selected using blasticydin for the 3 following days.

Apr 26, 2023 | nature.com | Pablo Gainza |Anthony Marchand |Andreas Scheck |Dongchun Ni |Shuguang Tan |Priscilla Turelli | +9 more

AbstractPhysical interactions between proteins are essential for most biological processes governing life1. However, the molecular determinants of such interactions have been challenging to understand, even as genomic, proteomic and structural data increase.