Dietrich Trümbach

Nov 22, 2023 | nature.com | Sebastian Schmidt |Duc Vu |Martin Regensburger |Ozge Karayel |Dietrich Trümbach |Martin Jastroch | +7 more

AbstractSporadic Parkinson’s Disease (sPD) is a progressive neurodegenerative disorder caused by multiple genetic and environmental factors. Mitochondrial dysfunction is one contributing factor, but its role at different stages of disease progression is not fully understood. Here, we showed that neural precursor cells and dopaminergic neurons derived from induced pluripotent stem cells (hiPSCs) from sPD patients exhibited a hypometabolism.