Martin Jastroch

Jan 13, 2025 | nature.com | Beatriz Cicuéndez |Juan Lopez |Juan López |Andrea Curtabbi |Javier Perez-Garcia |Daniel Jimenez-Blasco | +15 more

AbstractObesity poses a global health challenge, demanding a deeper understanding of adipose tissue (AT) and its mitochondria. This study describes the role of the mitochondrial protein Methylation-controlled J protein (MCJ/DnaJC15) in orchestrating brown adipose tissue (BAT) thermogenesis. Here we show how MCJ expression decreases during obesity, as evident in human and mouse adipose tissue samples.

Nov 22, 2023 | nature.com | Sebastian Schmidt |Duc Vu |Martin Regensburger |Ozge Karayel |Dietrich Trümbach |Martin Jastroch | +7 more

AbstractSporadic Parkinson’s Disease (sPD) is a progressive neurodegenerative disorder caused by multiple genetic and environmental factors. Mitochondrial dysfunction is one contributing factor, but its role at different stages of disease progression is not fully understood. Here, we showed that neural precursor cells and dopaminergic neurons derived from induced pluripotent stem cells (hiPSCs) from sPD patients exhibited a hypometabolism.

Jul 24, 2023 | nature.com | Martin Jastroch

Kang, Y. & Chen, L. Nature https://doi.org/10.1038/s41586-023-06332-w (2023). Article  Google Scholar  Jastroch, M., Divakaruni, A. S., Mookerjee, S., Treberg, J. R. & Brand, M. D. Essays Biochem. 47, 53–67 (2010). Article  PubMed  Google Scholar  Singh, A. M. et al. Nature Commun. 11, 2758 (2020). Article  PubMed  Google Scholar  Crichton, P. G., Lee, Y. & Kunji, E. R. S. Biochimie 134, 35–50 (2017). Article  PubMed  Google Scholar  Wu, X. & Rapoport, T. A. Proc. Natl Acad. Sci. USA 118, e2115001118 (2021).