Dingming Huang

2 months ago | nature.com | Liu Wang |Haohao Dong |Dingming Huang

AbstractCircularly permuted group II introns (CP introns) consist of rearranged structural domains separated by two tethered exons, generating branched introns and circular exons via back-splicing. Structural and mechanistic understanding of circular RNA (circRNA) generation by CP introns remains elusive. We resolve cryo-electron microscopy structures of a natural CP intron in different states during back-splicing at a resolution of 2.5–2.9 Å.

Jan 6, 2025 | nature.com | Zhuo Chen |Xi Wei |Yumei Niu |Dingming Huang |Zhengwei Huang |JinHua Yu | +1 more

AbstractPulpotomy, which belongs to vital pulp therapy, has become a strategy for managing pulpitis in recent decades. This minimally invasive treatment reflects the recognition of preserving healthy dental pulp and optimizing long-term patient-centered outcomes.