JinHua Yu

Jan 6, 2025 | nature.com | Zhuo Chen |Xi Wei |Yumei Niu |Dingming Huang |Zhengwei Huang |JinHua Yu | +1 more

AbstractPulpotomy, which belongs to vital pulp therapy, has become a strategy for managing pulpitis in recent decades. This minimally invasive treatment reflects the recognition of preserving healthy dental pulp and optimizing long-term patient-centered outcomes.

Jun 2, 2024 | nature.com | JinHua Yu

AbstractMethyltransferase-like 3 (METTL3) is a crucial element of N6-methyladenosine (m6A) modifications and has been extensively studied for its involvement in diverse biological and pathological processes. In this study, we explored how METTL3 affects the differentiation of stem cells from the apical papilla (SCAPs) into odonto/osteoblastic lineages through gain- and loss-of-function experiments.

Feb 29, 2024 | nature.com | Xin Xu |Xi Wei |Zhengwei Huang |JinHua Yu

AbstractEndodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by gutta-percha. However, it is very essential for endodontic treatment to debride the root canal system and prevent the root canal system from bacterial reinfection after root canal therapy (RCT).

Feb 29, 2024 | nature.com | Xin Zheng |Zhi Chen |Xi Wei |Xin Xu |JinHua Yu

AbstractChemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved, impeding irrigation efficacy and resulting in residual infections and compromised treatment outcomes. Additionally, ambiguous clinical indications for root canal medication and non-standardized dressing protocols must be clarified.