Dirk Schnappinger

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A BCG kill switch strain protects against Mycobacterium tuberculosis in mice and non-human primates with improved safety and immunogenicity - Nature Microbiology

Jan 9, 2025 | nature.com | Yao Liu |Pauline Maiello |Andrew Simonson |Mark Rodgers |Dirk Schnappinger |Sabine Ehrt

AbstractImproved vaccination strategies for tuberculosis are needed. Intravenous (i.v.) delivery of live attenuated Mycobacterium bovis BCG provides protection against Mycobacterium tuberculosis (Mtb) in macaques but poses safety challenges. Here we genetically engineered two strains, BCG-TetON-DL and BCG-TetOFF-DL, to either induce or inhibit expression of two phage lysin operons, respectively, upon tetracycline exposure.

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