Diwen Yang

2 weeks ago | biorxiv.org | Xiaoyun Wang |Jianxian Sun |Shabbir Ahmad |Diwen Yang

AbstractWe report an enantioselective protein affinity selection mass spectrometry screening approach (E-ASMS) that enables the detection of weak binders, informs about selectivity, and generates orthogonal confirmation of binding. After method development with control proteins, we screened 31 human proteins against a designed library of 8,210 chiral compounds.