Jianxian Sun

Mar 21, 2024 | nature.com | Jiabao Liu |Linhao Li |Holly Barrett |Jianxian Sun |William Navarre |Derek Wilson | +5 more

AbstractNumerous studies have demonstrated the correlation between human gut bacteria and host physiology, mediated primarily via nuclear receptors (NRs). Despite this body of work, the systematic identification and characterization of microbe-derived ligands that regulate NRs remain a considerable challenge. In this study, we discover a series of diindole molecules produced from commensal bacteria metabolites that act as specific agonists for the orphan constitutive androstane receptor (CAR).