Domenico Plantone

Jan 22, 2025 | journals.sagepub.com | Floriana De Angelis |Francesca Ammoscato |Richard Parker |Domenico Plantone

Introduction Multiple sclerosis (MS) is a chronic, immune-mediated disease of the central nervous system (CNS) characterized by inflammation, myelin and axonal injury.1 Axonal loss is a key pathological feature underpinning chronic disease deterioration, although synaptic damage and loss contribute.2 Axonal loss occurs throughout MS, mainly through two mechanisms: first, as a result of axonal transection in acutely inflamed focal lesions;1 and second, as a delayed degeneration from earlier...