Dongkyu Lee

Mar 4, 2024 | biorxiv.org | John Chen |Dongkyu Lee |Nobuhiko Tokuriki |Sevan Gholipour

AbstractMost antibiotic-resistance genes (ARGs) evolved in environmental microbes long before humanity's antibiotic breakthrough, and widespread antibiotic use expedited the dissemination of ARGs among clinical pathogens. While widely discussed, the investigation of environmental ARG distributions lacks the scalability and taxonomic information necessary for a comprehensive analysis. Here, we present a global distribution of all five classes of β-lactamases among microbes and environments.

Nov 28, 2023 | biorxiv.org | John Chen |Dongkyu Lee |Matteo Bisardi |Sabrina Cotogno

AbstractOver the course of evolution, proteins families undergo sequence diversification via mutation accumulation, with extant homologs often sharing less than 25% sequence identity. The resulting diversity presents a complex view of sequence-structure-function relationships, as epistasis is prevalent, and deleterious mutations in one protein can be tolerated in homologous sequences through networks of intramolecular, compensatory interactions.

Oct 17, 2023 | uxdesign.cc | Dongkyu Lee

Transition animations: a practical guidePrinciples that can be used immediately by anyone in their design process. When it comes to product design, the importance of animation and motion can’t be overstated. As highlighted by the Nielsen Norman Group, they not only attract attention but enhance user enjoyment and help your product feel fresh and modern. When an animation is sophisticated enough, it can give users clear feedback on their actions, making the interface feel more intuitive.

Oct 17, 2023 | uxdesign.cc | Dongkyu Lee

Principles that can be used immediately by anyone in their design process. When it comes to product design, the importance of animation and motion can't be overstated. As highlighted by the Nielsen Norman Group, they not only attract attention but enhance user enjoyment and help your product feel fresh and modern. When an animation is sophisticated enough, it can give users clear feedback on their actions, making the interface feel more intuitive.