Sevan Gholipour

Mar 4, 2024 | biorxiv.org | John Chen |Dongkyu Lee |Nobuhiko Tokuriki |Sevan Gholipour

AbstractMost antibiotic-resistance genes (ARGs) evolved in environmental microbes long before humanity's antibiotic breakthrough, and widespread antibiotic use expedited the dissemination of ARGs among clinical pathogens. While widely discussed, the investigation of environmental ARG distributions lacks the scalability and taxonomic information necessary for a comprehensive analysis. Here, we present a global distribution of all five classes of β-lactamases among microbes and environments.