Sevan Gholipour

1 month ago | biorxiv.org | Naoki Konno |Sevan Gholipour |John Chen |Morito Sakuma

AbstractPhosphate is often a limiting resource, directly affecting the availability of key biomolecules such as nucleotides. To cope with phosphate scarcity, bacteria have evolved enzymes that utilize alternative phosphorus compounds, including phosphite (Pt).

Mar 4, 2024 | biorxiv.org | John Chen |Dongkyu Lee |Nobuhiko Tokuriki |Sevan Gholipour

AbstractMost antibiotic-resistance genes (ARGs) evolved in environmental microbes long before humanity's antibiotic breakthrough, and widespread antibiotic use expedited the dissemination of ARGs among clinical pathogens. While widely discussed, the investigation of environmental ARG distributions lacks the scalability and taxonomic information necessary for a comprehensive analysis. Here, we present a global distribution of all five classes of β-lactamases among microbes and environments.