Dorothy Beckett

Sep 25, 2023 | jbc.org | Erik H. Klontz |Juliet O. Obi |Gabrielle Glendening |Dorothy Beckett

AbstractToll-like and Interleukin-1/18 receptor resistance (TIR) domain-containing proteins function as important signaling and immune regulatory molecules. TIR domain-containing proteins identified in eukaryotic and prokaryotic species also exhibit NAD+ hydrolase activity in select bacteria, plants, and mammalian cells.