Duo Xie

Oct 30, 2024 | nature.com | Duo Xie |Shanjun Deng |Kun Wang |Hao Zhang |Xuefei Li |Da Zhou | +5 more

AbstractUnravelling the origin and evolution of precancerous lesions is crucial for effectively preventing malignant transformation, yet our current knowledge remains limited1,2,3. Here we used a base editor-enabled DNA barcoding system4 to comprehensively map single-cell phylogenies in mouse models of intestinal tumorigenesis induced by inflammation or loss of the Apc gene.

Jun 24, 2024 | nature.com | Duo Xie |Zheng Hu

AbstractCancer is an evolutionary process shaped by selective pressure from the microenvironments. However, recent studies reveal that certain tumors undergo neutral evolution where there is no detectable fitness difference amongst the cells following malignant transformation.