Shanjun Deng

Oct 30, 2024 | nature.com | Duo Xie |Shanjun Deng |Kun Wang |Hao Zhang |Xuefei Li |Da Zhou | +5 more

AbstractUnravelling the origin and evolution of precancerous lesions is crucial for effectively preventing malignant transformation, yet our current knowledge remains limited1,2,3. Here we used a base editor-enabled DNA barcoding system4 to comprehensively map single-cell phylogenies in mouse models of intestinal tumorigenesis induced by inflammation or loss of the Apc gene.

Feb 20, 2024 | nature.com | Shanjun Deng

AbstractQuantifying the number of progenitor cells that found an organ, tissue or cell population is of fundamental importance for understanding the development and homeostasis of a multicellular organism. Previous efforts rely on marker genes that are specifically expressed in progenitors. This strategy is, however, often hindered by the lack of ideal markers.