Dustin Moraczewski

Sep 12, 2024 | nature.com | Rebecca Shafee |Dustin Moraczewski |Siyuan Liu |Travis T. Mallard |Adam Thomas

AbstractLarge biobanks have dramatically advanced our understanding of genetic influences on human brain anatomy. However, most studies have combined rather than compared male and female participants. Here we screen for sex differences in the common genetic architecture of over 1000 neuroanatomical phenotypes in the UK Biobank and establish a general concordance between male and female participants in heritability estimates, genetic correlations, and variant-level effects.