Travis T. Mallard

Sep 12, 2024 | nature.com | Rebecca Shafee |Dustin Moraczewski |Siyuan Liu |Travis T. Mallard |Adam Thomas

AbstractLarge biobanks have dramatically advanced our understanding of genetic influences on human brain anatomy. However, most studies have combined rather than compared male and female participants. Here we screen for sex differences in the common genetic architecture of over 1000 neuroanatomical phenotypes in the UK Biobank and establish a general concordance between male and female participants in heritability estimates, genetic correlations, and variant-level effects.

Jul 8, 2024 | nature.com | Camille Williams |Jakob Seidlitz |Travis T. Mallard

Correction to: Nature Mental Health https://doi.org/10.1038/s44220-024-00272-8, published online 4 July 2024. In the version of the article initially published, in Fig. 1e, arrows were missing between the “p” and “INT” circles, and between the “TD” circle and “BIP” square. The figure has now been corrected in the HTML and PDF versions of the article. About this articleWilliams, C.M., Peyre, H., Wolfram, T. et al.

Jul 3, 2024 | nature.com | Camille Williams |Jakob Seidlitz |Travis T. Mallard

AbstractMental health conditions are characterized by higher-order transdiagnostic factor structures, which may contribute to the high levels of comorbidity observed in psychopathology. However, the phenotypic and genetic structures of various psychopathology diagnoses may differ, raising questions about the validity and utility of these factors. Here we study the phenotypic and genetic factor structures of ten psychiatric conditions using UK Biobank and public genomic data.

Apr 16, 2024 | nature.com | Sylvanus Toikumo |Benjamin Pham |Travis T. Mallard |John J Meredith |Laura Vilar-Ribó |Emma Johnson | +14 more

AbstractTobacco use disorder (TUD) is the most prevalent substance use disorder in the world. Genetic factors influence smoking behaviours and although strides have been made using genome-wide association studies to identify risk variants, most variants identified have been for nicotine consumption, rather than TUD.

Dec 7, 2023 | nature.com | Hang Zhou |Rachel L. Kember |Joseph D. Deak |Travis T. Mallard |Jiayi Xu |Emma Johnson | +18 more

AbstractProblematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-related problems assessed with a questionnaire, is a leading cause of death and morbidity worldwide. Here we conducted a large cross-ancestry meta-analysis of PAU in 1,079,947 individuals (European, N = 903,147; African, N = 122,571; Latin American, N = 38,962; East Asian, N = 13,551; and South Asian, N = 1,716 ancestries).