Edward Wilson

Mar 27, 2024 | nature.com | Edward Wilson |Yann Le Guen |Eran Blacher |Matthew Xin |Melanie R. McReynolds |Chinyere A. Iweka

AbstractHuman genetics implicate defective myeloid responses in the development of late-onset Alzheimer disease. A decline in peripheral and brain myeloid metabolism, triggering maladaptive immune responses, is a feature of aging. The role of TREM1, a pro-inflammatory factor, in neurodegenerative diseases is unclear. Here we show that Trem1 deficiency prevents age-dependent changes in myeloid metabolism, inflammation and hippocampal memory function in mice.

Mar 11, 2024 | biorxiv.org | Katrin I. Andreasson |Edward Wilson |Congcong Wang |Matthew Xin

AbstractHuman genetics implicate defective myeloid responses in the development of late onset, age-associated Alzheimer disease (AD). Aging is characterized by a decline in myeloid metabolism that triggers maladaptive, neurotoxic immune responses. TREM1 is an amplifier of pro-inflammatory myeloid responses, and here we find that Trem1 deficiency prevents age-dependent changes in myeloid metabolism, inflammation, and hippocampal memory function.

Dec 6, 2023 | nature.com | Hamilton OH |Jarod Rutledge |Yun Ju Sung |Dan Western |Menghan Liu |Pat Kohlfeld | +9 more

AbstractAnimal studies show aging varies between individuals as well as between organs within an individual1,2,3,4, but whether this is true in humans and its effect on age-related diseases is unknown. We utilized levels of human blood plasma proteins originating from specific organs to measure organ-specific aging differences in living individuals.

Sep 21, 2023 | inkl.com | Edward Wilson

Mr Francis-Kerr, 29, died within an hour of being stabbed in the neck in what prosecutors say was a dispute over who was standing where in the nightclub.

Jul 26, 2023 | thepsp.in | Edward Wilson

Good Morning Bible Verses and Quotes: Mornings are uniquely important as they signify the beginning of a new day or something new. And how you start your day matters. So use these powerful and inspirational morning bible verses to start the day! Do you start your day with morning scriptures and prayer to God, or do you hustle into your hurly-burly life?