Katrin I. Andreasson

Mar 11, 2024 | biorxiv.org | Katrin I. Andreasson |Edward Wilson |Congcong Wang |Matthew Xin

AbstractHuman genetics implicate defective myeloid responses in the development of late onset, age-associated Alzheimer disease (AD). Aging is characterized by a decline in myeloid metabolism that triggers maladaptive, neurotoxic immune responses. TREM1 is an amplifier of pro-inflammatory myeloid responses, and here we find that Trem1 deficiency prevents age-dependent changes in myeloid metabolism, inflammation, and hippocampal memory function.

Dec 6, 2023 | nature.com | Hamilton OH |Jarod Rutledge |Yun Ju Sung |Dan Western |Menghan Liu |Pat Kohlfeld | +9 more

AbstractAnimal studies show aging varies between individuals as well as between organs within an individual1,2,3,4, but whether this is true in humans and its effect on age-related diseases is unknown. We utilized levels of human blood plasma proteins originating from specific organs to measure organ-specific aging differences in living individuals.