Ekaterina Laukhtina

Sep 12, 2024 | nature.com | Akihiro Matsukawa |Takafumi Yanagisawa |Marcin Miszczyk |Ichiro Tsuboi |Ekaterina Laukhtina |Juan Rivas | +4 more

AbstractRecent advancements in the management of biochemical recurrence (BCR) following local treatment for prostate cancer (PCa), including the use of androgen receptor signaling inhibitors (ARSIs), have broadened the spectrum of therapeutic options. We aimed to compare salvage therapies in patients with BCR after definitive local treatment for clinically non-metastatic PCa with curative intent.

Sep 4, 2024 | nature.com | Akihiro Matsukawa |Takafumi Yanagisawa |Ekaterina Laukhtina |Takahiro Kimura |Pawel Rajwa

AbstractAndrogen-receptor pathway inhibitors (ARPIs) have dramatically changed the management of advanced/metastatic prostate cancer (PCa). However, their cardiovascular toxicity remains to be clarified.

Nov 17, 2023 | nature.com | Ekaterina Laukhtina |Shahrokh F. Shariat

Neoadjuvant cisplatin-based combination chemotherapy followed by radical cystectomy with pelvic lymphadenectomy is the current standard therapy for cisplatin-eligible patients with muscle-invasive bladder cancer (MIBC). A phase II trial testing treatment intensification by adding the immune-checkpoint inhibitor nivolumab to chemotherapy has yielded promising complete response rates, which suggests that bladder-preserving treatment could become attainable in selected patients.

Aug 10, 2023 | bjui-journals.onlinelibrary.wiley.com | Ekaterina Laukhtina |Markus von Deimling |Benjamin Pradere |Takafumi Yanagisawa

BCa bladder cancer EORTC-QLQ-C30 European Organization for Research and Treatment of Cancer–Quality of Life Questionnaire–Cancer 30 FSFI Female Sexual Function Index HRQOL health-related quality of life IC ileal conduit ISC intermittent self-catheterization NSRC nerve-sparing radical cystectomy ONB orthotopic neobladder RC radical cystectomy ROBINS-I Risk of bias in non-randomized studies of interventions tool ROPRC reproductive organ-preserving radical cystectomy SF short-form Introduction...

Jul 18, 2023 | nature.com | Ekaterina Laukhtina

The relationship between smoking, ethnicity and bladder cancer is complex and multifaceted, with substantial public and personal health as well as clinical implications. New evidence supports that targeted smoking cessation efforts among high-risk populations could reduce the burden of bladder cancer. Refers to Liu, Y., Zhao, Y. C., Lu, Y., Goodarz, D. & Gershman, B. The role of smoking in explaining racial/ethnic disparities in bladder cancer incidence in the United States. Urol. Oncol.