Elana Apfelbaum

Oct 25, 2024 | biorxiv.org | Ali Sonay |Jan Grimm |Ny Usa |Elana Apfelbaum

AbstractFerroptosis emerged as a cell death modality for drug resistant cancer cells, but there are currently no available biomarkers for imaging ferroptosis based therapies. To address this gab, we evaluated the nanodynamic changes in lipid membranes occurring during cell death to explore potential targeting opportunities to image cell death. We nano-sized gaps at late stages of ferroptosis can serve as entry points for dyes that can bind to cellular structures.