Elena E. Pohl

Jul 25, 2024 | dx.doi.org | Wouter van Bergen |Kristina Zuna |Jan Fiala |Elena E. Pohl

IntroductionClick to copy section linkSection link copied!Small molecule drugs interact with proteins, affecting protein conformation, activity, and protein–protein interactions. (1−4) Drug–protein affinity is governed by interactions between the drug and amino acid side chains. (5) Even subtle chemical modifications of drugs can markedly alter their affinity toward their protein targets, reshaping the target landscape.