Jan Fiala

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Articles

Dual-Probe Activity-Based Protein Profiling Reveals Site-Specific Differences in Protein Binding of EGFR-Directed Drugs

Jul 25, 2024 | dx.doi.org | Wouter van Bergen |Kristina Zuna |Jan Fiala |Elena E. Pohl

IntroductionClick to copy section linkSection link copied!Small molecule drugs interact with proteins, affecting protein conformation, activity, and protein–protein interactions. (1−4) Drug–protein affinity is governed by interactions between the drug and amino acid side chains. (5) Even subtle chemical modifications of drugs can markedly alter their affinity toward their protein targets, reshaping the target landscape.
Projectile Motion: More Geometry, More Physics

Mar 8, 2024 | dialnet.unirioja.es | Jan Fiala

ResumenImagine getting an email from the Projectile Motion lab, where Alice and Bob are testing a new launcher in one of the best vacuum chambers in the world. Bob has used the same projectile each time, and all the launcher settings have remained the same except for the launch angle. Alice captured the movement of the projectile on a high-speed camera to see what shape its trajectory was.
Dual-Probe Activity-Based Protein Profiling Reveals Site-Specific Differences in Protein Binding of EGFR-Directed Drugs

Oct 19, 2023 | biorxiv.org | Wouter van Bergen |Jan Fiala |Albert J.R. Heck |Marc baggelaar

AbstractComparative, dose-dependent analysis of interactions between small molecule drugs and their targets, as well as off-targets, in complex proteomes is crucial for selecting optimal drug candidates. The affinity of small molecules for targeted proteins is largely dictated by interactions between amino acid side chains and these drugs. Thus, studying drug-protein interactions at an amino acid resolution provides a comprehensive understanding of drug selectivity and efficacy.
K právům a povinnostem učitelů

Mar 27, 2023 | pravniprostor.cz | Jan Fiala

PortálČlánkyK právům a povinnostem učitelů27.03.2023 / 11:49V lednu byl na webu Právního prostoru zveřejněn dvojdílný článek „20 otázek: co učitelé smějí a co nesmějí, ale přesto to často dělají“.[1] S některými závěry se neztotožňuji, a proto se k tématu vracím. Ke všem 20 otázkám připojuji svůj pohled. Práva a povinnosti učitelů upravují zejména § 3 a 6 vyhlášky č. 263/2007 Sb., § 22a a 22b školského zákona, významné jsou i zásady vzdělávání podle § 2 odst. 1 školského zákona.