Elena Emili

1 month ago | science.org | Barbara von Hippel |Jinke Chang |Christopher A. Waudby |Elena Emili |Sarah M. Lowen |Alistair M. Jagger | +6 more

AbstractSerpins, protease inhibitors whose regulated conformational instability renders them susceptible to mutations that cause misfolding, represent a system for the study of non-amyloid protein aggregation. The E342K “Z” variant of α-1-antitrypsin (AAT) undergoes oligomeric self-assembly into polymer chains that are associated with liver and lung pathologies in AAT deficiency.

1 month ago | science.org | Barbara von Hippel |Jinke Chang |Elena Emili |Joost Kimpel |Youngseok Kim |Hannes Schomaker | +6 more

AbstractConjugated polymers are widely studied for application areas ranging from energy technology to wearable electronics and bioelectronics. To develop a truly sustainable technology, environmentally benign synthesis is essential. Here, the open-flask synthesis of a multitude of conjugated polymers at room temperature by ambient direct arylation polymerization (ADAP) is demonstrated.