Elizabeth R. Gavis

Sep 9, 2024 | biorxiv.org | Zoya Gauhar |Cameron Myhrvold |Elizabeth R. Gavis

AbstractRibonucleoprotein (RNP) germ granules are hallmarks of germ cells across the animal kingdom and are thought to be hubs for post-transcriptional regulation that promote formation of the germ cell precursors. While numerous RNAs are associated with germ granules in Drosophila, the functions of many in germline development are poorly understood. Current methods for RNA knockdown, such as RNAi, do not allow local depletion of transcripts such as those found in the germ granules.

Apr 13, 2023 | journals.plos.org | New jersey |Elizabeth R. Gavis |Anna C. Hakes

Recruitment of decapping factors to germ granules requires translationOur results suggest that there is a temporally regulated, ordered recruitment of the mRNA decay machinery to germ granules. We therefore sought to determine the nature of the trigger that initiates this recruitment.