Cameron Myhrvold

Oct 11, 2024 | nature.com | Sreekar Mantena |Brittany A. Petros |Cameron Myhrvold |Pardis Sabeti

AbstractCRISPR guide RNA sequences deriving exactly from natural sequences may not perform optimally in every application. Here we implement and evaluate algorithms for designing maximally fit, artificial CRISPR–Cas13a guides with multiple mismatches to natural sequences that are tailored for diagnostic applications.

Sep 9, 2024 | nature.com | Coleen Murphy |Cameron Myhrvold

AbstractDetecting chemical signals is important for identifying food sources and avoiding harmful agents. Like many animals, C. elegans use olfaction to chemotax towards their main food source, bacteria. However, little is known about the bacterial compounds governing C. elegans attraction to bacteria and the physiological importance of these compounds to bacteria.

Sep 9, 2024 | biorxiv.org | Zoya Gauhar |Cameron Myhrvold |Elizabeth R. Gavis

AbstractRibonucleoprotein (RNP) germ granules are hallmarks of germ cells across the animal kingdom and are thought to be hubs for post-transcriptional regulation that promote formation of the germ cell precursors. While numerous RNAs are associated with germ granules in Drosophila, the functions of many in germline development are poorly understood. Current methods for RNA knockdown, such as RNAi, do not allow local depletion of transcripts such as those found in the germ granules.

Nov 30, 2023 | biorxiv.org | Jacob G Marogi |Coleen Murphy |Cameron Myhrvold |Zemer Gitai

AbstractDetecting chemical signals is important for identifying food sources and avoiding harmful agents. Like most animals, C. elegans use olfaction to chemotax towards their main food source, bacteria. However, little is known about the bacterial compounds governing C. elegans attraction to bacteria and the physiological importance of these compounds to bacteria.

May 26, 2023 | pubmed.ncbi.nlm.nih.gov | Shruti Sharma |Cameron Myhrvold

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