Ellen S. Kakulidis

Aug 4, 2024 | nature.com | Zita Fábián |Ellen S. Kakulidis |Ivo A. Hendriks |Ulrike Kühbacher |Nicolai B. Larsen |Marta Oliva-Santiago | +4 more

AbstractDNA-protein crosslinks (DPCs) are toxic lesions that inhibit DNA related processes. Post-translational modifications (PTMs), including SUMOylation and ubiquitylation, play a central role in DPC resolution, but whether other PTMs are also involved remains elusive. Here, we identify a DPC repair pathway orchestrated by poly-ADP-ribosylation (PARylation).