Elmarakeby HA

Mar 1, 2024 | aacrjournals.org | S’ Disclosures |Elmarakeby HA

DNA replication is central to cell division and proliferation, involving closely orchestrated functions among hundreds of proteins (1, 2). Although the replication machinery is highly accurate, it faces challenges from both extrinsic and intrinsic factors (3). These challenges can result in stalled replication forks, occurrence of DNA breaks, reduced replication precision, and other factors collectively known as RS (4).

Jul 20, 2023 | ascpt.onlinelibrary.wiley.com | Yun Hao |Joseph Romano |Jason Moore |Elmarakeby HA

Abstract In computational toxicology, prediction of complex endpoints has always been challenging, as they often involve multiple distinct mechanisms. State-of-the-art models are either limited by low accuracy, or lack of interpretability due to their black-box nature. Here, we introduce AIDTox, an interpretable deep learning model which incorporates curated knowledge of chemical-gene connections, gene-pathway annotations, and pathway hierarchy.