Joseph Romano

Nov 28, 2024 | biorxiv.org | Rachit Kumar |Joseph Romano |Marylyn D. Ritchie

AbstractAccurately determining the binding affinity of a ligand with a protein is important for drug design, development, and screening. With the advent of accessible protein structure prediction methods such as AlphaFold, several approaches have been developed that make use of information determined from the 3D structure for a variety of downstream tasks.

Jan 9, 2024 | lexology.com | Joseph Romano

Employers and workers’ compensation insurance carriers in Pennsylvania recently obtained a significant victory in the Commonwealth Court. In Federated Insurance Company v. Summit Pharmacy (Bureau of Workers’ Compensation Peer Review Office), the Commonwealth Court determined that employers and carriers are not bound by the prescription reimbursements as defined by the Red Book and, instead, are only required to pay 110% of the average wholesale price.

Jul 20, 2023 | ascpt.onlinelibrary.wiley.com | Yun Hao |Joseph Romano |Jason Moore |Elmarakeby HA

Abstract In computational toxicology, prediction of complex endpoints has always been challenging, as they often involve multiple distinct mechanisms. State-of-the-art models are either limited by low accuracy, or lack of interpretability due to their black-box nature. Here, we introduce AIDTox, an interpretable deep learning model which incorporates curated knowledge of chemical-gene connections, gene-pathway annotations, and pathway hierarchy.