ELTE Eötvös Loránd

Oct 17, 2024 | bmcbioinformatics.biomedcentral.com | ELTE Eötvös Loránd

The mulea R package addresses the limitations of traditional enrichment analysis methods by offering a comprehensive and flexible toolkit. It tackles the issue of overcorrected p-values through a robust empirical false discovery rate (eFDR) method, specifically designed for interconnected biological data. mulea also goes beyond existing tools (Table 1) by incorporating a wide range of ontologies encompassing Gene Ontology, pathways, regulatory elements, genomic locations, and protein domains.

Oct 2, 2024 | bmcpsychiatry.biomedcentral.com | ELTE Eötvös Loránd |Eötvös Loránd

ReferencesAmerican Psychiatric Association. Diagnostic and statistical Manual of Mental disorders: DSM-5-TR. 5th ed. text rev: Author; 2022. Book  Google Scholar  Isohanni M, Jones PB, Moilanen K, Rantakallio P, Veijola J, Oja H, Koiranen M, Jokelainen J, Croudace T, Järvelin M-R. Early developmental milestones in adult schizophrenia and other psychoses. A 31-year follow-up of the Northern Finland 1966 Birth Cohort. Schizophr Res. 2001;52:1–19.

Aug 7, 2024 | bmcgenomics.biomedcentral.com | ELTE Eötvös Loránd

Functional changes driven by intronic TEs have been well studied, although typically, such TEs are large in size and physically proximal to the nearest exon (i.e., within 100 nucleotides) or splice sites [56,57,58]. Our work confirms that the polymorphic 187 bp intronic TE alters cis-regulatory landscapes within CFA6:5.7–6.3 Mb, by impacting the chromatin structure itself. The TE promotes altered looping with intron 1 of GTF2I, which are further associated with differences in gene regulation.

Jul 30, 2024 | academic.oup.com | ELTE Eötvös Loránd

Contextual features are integral to episodic memories; yet, we know little about context effects on pattern separation, a hippocampal function promoting orthogonalization of overlapping memory representations. Recent studies suggested that various extrahippocampal brain regions support pattern separation; however, the specific role of the parahippocampal cortex—a region involved in context representation—in pattern separation has not yet been studied.

Jul 10, 2024 | bmcpregnancychildbirth.biomedcentral.com | ELTE Eötvös Loránd

Our quantitative, cross-sectional study analysed the circumstances and events of childbirth, highlighting the occurrence of obstetric interventions, the type of delivery and the characteristics of infant feeding, to identify possible associations that could reduce the extent of interventions that negatively affect breastfeeding. Our quantitative, cross-sectional study was conducted online with a nonrandom, targeted sampling method between 26 March and 18 July 2021.