Emil Uffelmann

May 4, 2023 | biorxiv.org | Emil Uffelmann |Christiaan de Leeuw |Danielle Posthuma |Vrije Universiteit Amsterdam

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Mar 14, 2023 | nature.com | Emil Uffelmann |Danielle Posthuma

Introductionarising from: C. Gouveia et al.; Scientific Reports https://doi.org/10.1038/s41598-022-12391-2 (2022). Gouveia and colleagues (2022)1 conducted a genome-wide association study (GWAS) of a polygenic risk score (PRS)-derived phenotype (N = 37,784), in which they identified 246 independent loci and 473 lead SNPs. This is an enormous increase compared to the most recent and largest GWAS of AD2 (N = 1,126,563), which identified 38 loci.